Grady Sizemore led off the first in style by hitting a triple. Dustin Pedroia wasted no time in driving home the first run of the night and becoming the first player to get a hit off Michael Pineda while batting second. The Red Sox would score another run in the first when A.J. Pierzynski drove in Pedroia with a single to center field.
The bottom of the second had some excitement as Pineda got called out for getting a little help from some pine tar on his neck. After being inspected by the umpires, Pineda was ejected. (read my thought on this topic here)
The Red Sox added to their lead in the 3rd when 8 players went to the plate. It started with Pedroia reaching via a Derek Jeter error. Pedroia would eventually score on a Mike Napoli ground rule double. Ortiz would also add a run when he came home on a David Phelps wild pitch.
Besides being embarrassed with the situation during the second inning, the Yankees were also humbled with their 3 errors. With the Red Sox scoring 2 unearned runs, the errors were costly. Of course, since Lackey only gave up 1 run, the additional scores did not have an effect on the outcome.